There have been many studies done to reveal that Cissus Quadrangularis prevents Osteoporosis and promotes stronger, healthier bones. Cissus has been used for many centuries to heal bone fractures and reduce inflammation to injured muscles and bones. In osteoporosis, the bone mineral density (BMD) is reduced, bone microarchitecture deteriorates, and the amount and variety of proteins in bone are altered. There have been many theories to what causes osteoporosis and what can prevent it. Many drugs that are offered can be dangerous due to the side effects. Calcium supplements were said to prevent osteoporosis, but actually don’t because many times the body is unable to absorb the calcium, and this is the reason for the bone deterioration in the first place.
Study showing Cissus Quadrangularis Prevents Osteoporosis
A study done to evaluate the effects of the petroleum ether extract of Cissus quadrangularis on the proliferation rate of bone marrow mesenchymal stem cells shows that Cissus quadrangularis stimulates osteoblastogenesis and can be used as preventive/alternative natural medicine for bone diseases such as osteoporosis.
Mesenchymal stem cells(MSC’s) were cultured in media with or without Cissus quadrangularis for 4 weeks and were then stained for alkaline phosphatase.
The results showed treatment with 100, 200 or 300 µg/mL petroleum ether extract of Cissus quadrangularis enhanced the differentiation of marrow mesenchymal stem cells into ALP-positive osteoblasts and increased extracellular matrix calcification.
Human bone is composed of a mineralized organic matrix and bone cells. Osteoblasts are active mature bone cells that synthesize the organic matrix and regulate the mineralization process. Osteogenesis begins with osteoblast formation and secretion of type I collagen, which makes up about 90% of the organic bone matrix, or the osteoid.
The results clearly show that the Cissus Quadrangularis plant extract enhances the proliferation and differentiation ability of Mesenchymal stem cells into osteoblasts.
Cissus Quadrangularis is an ancient medicinal plant native to the hotter parts of Ceylon and India. Cissus Quadrangularis was prescribed in the ancient Ayurvedic texts as a general tonic and analgesic, with specific bone fracture healing properties. Modern research has shed light on Cissus’ ability to speed bone healing by showing it acts as a glucocorticoid antagonist (1,2).
Since anabolic/androgenic compounds are well known to act as antagonists to the glucocorticoid receptor as well as promote bone growth and fracture healing, it has been postulated that Cissus Quadrangularis possesses anabolic and/or androgenic properties (1,3). In addition to speeding the remodeling process of the healing bone, Cissus Quadrangularis also leads to a much faster increase in bone tensile strength.
In clinical trials Cissus Quadrangularis has led to a fracture healing time on the order of 55 to 33 percent of that of controls. That cissus exerts antiglucocorticoid properties is suggested by a number of studies where bones were weakened by treatment with cortisol, and upon administration of Cissus Quadrangularis extract the cortisol induced weakening was halted, and the healing process begun.
While the increased rate of bone healing may be of great significance to persons suffering from chronic diseases like osteoporosis (4), the antiglucocorticoid properties of Cissus Quadrangularis are likely of much more interest to the average bodybuilder or athlete, since endogenous glucocorticoids, particularly cortisol, are not only catabolic to bone, but catabolize muscle tissue as well.
Numerous studies over the years have suggested that glucorticoids, including the body’s endogenous hormone cortisol activate pathways that degrade not only bone, but skeletal muscle tissue as well. A recently published report documented exactly how glucocorticoids (including cortisol) induce muscle breakdown: They activate the so-called ubiquitin-proteasome pathway of proteolysis (5). This pathway of tissue breakdown is important for removing damaged and non-functional proteins.
However, when it is overactive during periods of elevated cortisol (e.g disease states, stress, and over-training) excess amounts of normal tissue are broken down as well. By exerting an anabolic, antiglucorticoid effect Cissus Quadrangularis helps preserve muscle tissue during times of physical and emotional stress.
Although the bulk of the research on Cissus Quadrangularis centers around bone healing, the possibility exists that Cissus may act to improve bone healing it may improve the healing rate of connective tissue in general, including tendons. If this is the case it would be of great benefit to bodybuilders and athletes.
Besides the above-mentioned properties of Cissus Quadrangularis, the plant is also rich in the vitamins/antioxidants vitamin C and beta-carotene. As analyzed, Cissus quadrangularis contained ascorbic acid 479 mg, and carotene 267 units per 100g of freshly prepared paste in addition to calcium oxalate (6).
The typical recommended daily dosage of Cissus Quadrangularis is 1-2 grams to accelerate fracture healing. Safety studies in rats showed no toxic effects at dosages as high as 2000 mg/kg of body weight. So not only is Cissus efficacious, it is also quite safe, in either the dried powder form or the commercially available extract.
Cissus Quadrangularis also possess analgesic properties on a mg per mg basis comparable to aspirin or anti-inflammatory drugs like ibuprofen. Cissus quadrangularis, which has been proved to be highly effective in relieving pain, reduction of swelling and promoting the process of healing of the simple fractures as well as in curing the allied disorders associated with fractures (7). The mechanism through which Cissus Quadrangularis exerts its analgesic and anti-inflammatory properties has not been well characterized. It may act centrally, but the anti-inflammatory features suggest that it acts by preventing the conversion of arachidonic acid to inflammatory prostaglandins. Real World Application for injuries.
Simply if you’re suffering from joint pain, ligament pain, cartilage pain, had surgery on bone, ligament or cartilage, Cissus is the supplement to use. It has been my experience that many athletes take anti-inflammatory medications to fight through the pain. Ultimately, these medications only kill the sensation of pain not the symptom. Cissus has the ability to kill the pain specific to the injury while promoting healing.
Some users will get instant relief and other will need to use Cissus for much longer period of time for complete healing of an injury. Leverage performance science is not claiming that Cissus will work 100% percent of the time that would be a foolish claim. We have estimated that 85% of user experience relief from our product. This number may lower or rise as more consumers send in reports. In the PHARMACEUTICAL industry a 50% success rate is good. Since we’re talking about the Pharmaceutical industry, they have yet to produce a product that helps the healing process. They just develop pain medications that are often addicting.
One of the most important questions you may have about Cissus is…
“How much Cissus should I take? What is the correct Cissus Dosage”
Cissus is a completely safe, natural herb that has virtually no track record of causing bodily harm. With that said, you will not overdose on cissus.
The recommended dosage may vary depending on what you are using Cissus for. Cissus can be used for bodybuilding/muscle building, bone/tendon/muscle repair, overall fitness, weight loss, and other uses.
When taking a Cissus Extract such as Muscle Defense, we would recommend starting with 800mg – 1000mg per serving taken 2-3 times a day. You may increase your dosage as you feel fit. We feel anymore than 2000mg of cissus may be a waste as your body will most likely excrete most of the cissus it does not use. Remember that cissus inhibits cortisol levels, but does not 100% stop cortisol, making it a safe, natural way to inhibit cortisol.
When taking cissus for an overall fitness or weight loss the dosage may be a little less. You can keep it in the 600mg-1000mg range. Again, depending on how your body is reacting you may increase the dosages. Taking cissus 30 minutes prior to meals is the most effective way to dose. Cissus may help control your appetite and controls the amount of sugars and fats your body produces and stores.
In extreme cases, such as bone fractures or torn tendons, athletes may want to take heavy doses around the 2000mg level. The most effective cissus extract products come in capsule form with anywhere from 500mg to 800mg of extract powder per capsule. We would suggest taking 2-3 capsules per serving(or 4 in extreme cases).
Allow at least a week or 2 for the full effects of cissus quadrangularis to take. You body will adjust to having this new herb affecting cortisol levels, and just like any other natural substance it may take some time for you body to adjust. We suggest taking cissus for at least 2 months to allow cissus to completely heal any injuries. For weight loss we suggest using lower doses of cissus over longer periods of time.
Whatever your reason for finding Cissus and using it as part of your daily regiment, just be confident you have found an amazing, natural herb that is completely safe. If you do feel any adverse affects you may want to consult your physician to see if you are allergic to cissus.
Finally, you can gain the muscle you work so hard to develop…Injury Free!
An Amazing Discovery Gains You Massive Muscle Mass. 100% Natural. A SouthEast Asian Ancient Secret Revealed!
It works like magic but almost nobody knows about it.
You’ll ask yourself, how can something 100% natural be so powerful… and so secret –
That’s the way the bodybuilding companies like it.
Hi, Ken Here from Cissus Experts. I’d like to give you an overview of Cissus, an extremely popular new supplement in the Health and Fitness community.
Increase your overall strength of the body
Maintain Body Weight
Mend, Repair, and Protect your body from Injuries
How can one supplement do all that?
Cissus Quadrangularis was originally written about in a Yoga text Ayurveda. It’s in the grape family, and we all know how the anti-oxidents of wine have be shown to protect the body. Well, Cissus is in the same family as the wine grape.
It’s more powerful and potent than most anti-oxidents found.
So why is Cissus Quadrangularis so hidden from the mainstream market?
Cissus only grows in a few places in the world and it has been marketed for many different uses, but none as popular as the Weight Loss and Weight Lifting communities.
It is grown in SouthEast Asia and India and it is even rare to find throughout these areas.
How did I stumble upon Cissus Quadrangularis?
While traveling through Southeast Asia, I ruptured my Achilles Tendon. Not a good injury to have while trekking around.
I was DESPERATE!
I started looking up muscle and ligament repair and found Cissus and saw that it can be found in SouthEast Asia, EXACTLY where I was!
I found out the local name for it and found a bottle of capsules that was being marketed for hemorrhoids.
Apparently the list of Cissus cures goes on and on…
The results were AMAZING!
My Achilles Tendon was healing in record time. My doctor told me I wouldn’t be walking on it for another 2 months. Well, in just 3 weeks I was putting pressure on it.
I hadn’t exercised for a couple months and, being an avid athlete, was feeling lathargic to say the least, but to my suprise I didn’t gain an ounce of fat and my muscle tone had actually improved!
To make a long story short I felt I owed it to this Miracle Herb to share it’s powers with the world. I instantly set up an office in SouthEast Asia began my plan of how to get the most potent Cissus Quadrangulris to the people who can benefit from it the most….and I’m not talking about Hemorrhoids.
My research found the best Cissus Extract on the market at very affordable prices.
What is Cissus Quadrangularis? Cissus is commonly known as Veld Grape, which as the name suggests, puts it into the grape family. It has been called the “Devil’s Backbone” due to its physical appearance. In Thailand cissus is called
Phet Sang Kart(เพชรสังฆาต). You will also see the word “ketosterones” which are plant sterols and are the active ingredient for muscle defense, joint health, tendon recovery, and many other benefits we will be discussing.
Discovery of Cissus
No, we did not discover cissus, but we would like to re-introduce this amazing herb back into our modern day society. Cissus has been used by ancient civilizations for many different uses. Cissus Quadrangularis was originally written about in an Ayurveda Yoga text. It was used primarily to heal bone fractures and torn ligaments. Since it is mostly found throughout India and Southeast Asia, it was mostly these civilizations who have recorded the most uses of cissus. It has been used orally and topically, and not all of the benefits were recorded from ancient history as ones such as weight loss was probably not a hot topic back then. We have been discovering more and more benefits the more we research cissus quadrangularis.
Uses and Benefits of Cissus
Now that we know what is Cissus Quadrangularus, let’s take a look at the benefits. Cissus can be found(more hidden) in many supplements and medications. Cissus can be taken as an extract or blended with other supplements. The list of benefits goes on and on as we discover more about this ancient medicinal herb.
Muscle Repair – Cissus is used by body builders to repair torn muscles, ligaments, and bones. It can be used by all athletes who suffer bone fractures or torn tendons such as ACL/MCL tears, Achilles tendon tears, or any joint/tendon injury.
Joint Health – Cissus is a natural joint health supplement similar to DHEA or MSM. Cissus allows for joint, tendon, and ligament repair.
Bone Support – A latest study shows that cissus directly helps bone marrow make the bone-building cells known as osteoblasts as well as directly promote the formation of calcium matrix (new bone)
Workout Recovery – Cissus can improve your workout recovery time and allow your body to gain maximum benefits from over strenuous exercise.
Cortisol Blocker – This is one of the main goals of body builders since cortisol, a natural hormone in our bodies, breaks down muscle when they are stressed. This means cortisol is working against heavy workouts. By blocking cortisol your body allows muscles to get ripped. Cortisol also plays a part in breaking down sugars and amino acids which can get stored as fats, another thing bodybuilders don’t want.
Weight Loss/Management – When we are stressed, either physically, mentally, or emotionally, our bodies send out hormones to defend itself. Cortisol is one hormone our bodies send out. What happens then is our body finds sugars to break down to store as fat in order to protect our cells from stress. Cissus prevents the cortisol from interfering with our muscle growth and prevents the fat build up.
Anti-Oxidant – Cissus is in the grape family and therefore carries great anti-oxidant properties for the human body. This makes cissus healthy for everyone.
Gastroprotective Activity- Cissus has been used to treat hemorrhoids and other digestive aids such as ulcers, asthma, and constipation – all important issues that are associated with bacterial imbalance in the digestive tract.
Malaria – Cissus has been used by Africans to relieve symptoms of Malaria
How to take Cissus Quadrangularis
All parts of Cissus quadrangularis are usable, including the stem, leaf, flower and fruit. Throughout history cissus has been used topically and orally. Currently cissus is used in nutritional suppliements. The plant can be broken down into a powder which can be just the plant itself or the extract, which is a more potent form. For athletes the extract form is the most useful way to take cissus. The taste may be bitter making capsule form the best way to take it.
The recommended dosages of cissus is anywhere from 600mg to 1000mg per serving. Studies have found that cissus is most effective when taken 30 minutes prior to meals. Servings may be taken 2-3 times per day. Like any other herbal supplement, your body may have different reactions to the newly introduced supplement. Some people see and feel results within 1 week, while others may not feel the effects of cissus for 1-3 months. Your dosage may be increased over time.
Studies done with Cissus
A study was undertaken to evaluate the effect of methanolic extract of Cissus quadrangularis Linn (CQ) on the healing process of experimentally fractured radius–ulna of dog. CQ treated animals revealed faster initiation of healing process than the control animals on radiological and histopathological examinations. The treated group also revealed a decrease in serum calcium level to a greater extent than the control group. Healing was almost complete on 21 st day of fracture in the treated animals and remained incomplete in the control animals. No significant alteration ofserum calcium level was observed on 21 st day of fracture in both the groups.
When you’re looking for a cissus supplement, you will want to find a pure extract preferably in capsule form. While cissus comes in powder, it has a strong, bitter taste and may be difficult for you to measure correct amounts.
Muscle Defense – Pure cissus extract from Thailand. This is the most pure cissus you can find. It comes in 500mg capsules for 60 servings. Serving suggestion is 1000mg per serving.
Super Cissus RX – A cissus extract at 800mg per serving. It is not a very potent extract and the servings actually suggest 1600mg for therapeutic use.
Any Questions about cissus and its uses please contact us, the Cissus Experts and/or leave comments below.
Cissus quadrangularis is used for obesity, diabetes, a cluster of heart disease risk factors called “metabolic syndrome,” and high cholesterol. It has also been used for bone fractures, weak bones (osteoporosis), scurvy, cancer, upset stomach, hemorrhoids, peptic ulcer disease (PUD), painful menstrual periods, asthma, malaria, and pain. Cissus quadrangularis is also used in bodybuilding supplements as an alternative to anabolic steroids.
Cissus can be found (more hidden) in many supplements and medications. Cissus can be taken as an extract or blended with other supplements. The list of benefits goes on and on as we discover more about this ancient medicinal herb.
Cissus Muscle Repair
Cissus is used by body builders to repair torn muscles, ligaments, and bones. It can be used by all athletes who suffer bone fractures or torn tendons such as ACL/MCL tears, Achilles tendon tears, or any joint/tendon injury.
Cissus is a natural joint health supplement similar to DHEA or MSM. Cissus allows for joint, tendon, and ligament repair.
A latest study shows that cissus directly helps bone marrow make the bone-building cells known as osteoblasts as well as directly promote the formation of calcium matrix (new bone)
Cissus can improve your workout recovery time and allow your body to gain maximum benefits from over strenuous exercise.
This is one of the main goals of body builders since cortisol, a natural hormone in our bodies, breaks down muscle when they are stressed. This means cortisol is working against heavy workouts. By blocking cortisol your body allows muscles to get ripped. Cortisol also plays a part in breaking down sugars and amino acids which can get stored as fats, another thing bodybuilders don’t want.
When we are stressed, either physically, mentally, or emotionally, our bodies send out hormones to defend itself. Cortisol is one hormone our bodies send out. What happens then is our body finds sugars to break down to store as fat in order to protect our cells from stress. Cissus prevents the cortisol from interfering with our muscle growth and prevents the fat build up.
Cissus Anti-Oxidant Properties
Cissus is in the grape family and therefore carries great anti-oxidant properties for the human body. This makes cissus healthy for everyone. Most of the diseases and problems that cissus can be used to aid come down to fighting oxidants in our bodies. Digestive problems are the root of most of our health problems and the main cause of poor digestion is all the oxidants our bodies are fighting everyday.
Cissus has been used to treat hemorrhoids and other digestive aids such as ulcers, asthma, and constipation – all important issues that are associated with bacterial imbalance in the digestive tract.
Cissus has been used by Africans, for centuries, to relieve symptoms of and prevent Malaria. The cissus plant contains anti-malaria agents that can subdue the effects of malaria.
Cissus promotes estrogenic activity, mostly in rats that are a research model for menopause. It has not been investigated as to whether this estrogenic activity influences male performance or sexuality, however.
Cissus Quadrangularis carries high levels of carotene and antioxidants making it an aid in fighting most diseases, especially in the ears and eyes.
Anorexia is not just some teenager deciding to get thin by CHOOSING not to eat, but rather a disease that can be brought on by chemical imbalances within the body and/or by digestive problems.
Cissus quadrangularis contains a variety of phytonutrients such as quercetin, stillbenes, beta carotene, and other flavonoids. These nutrients help your digestive lining in several ways including preventing gastric damage, boosting antioxidant function, reducing inflammation, and preserving the capillary integrity and normal function of your stomach and digestive lining.
The weight loss effects of Cissus are not mainly appetite suppression, but rather the fact that by inhibiting cortisol you are also inhibiting the liver to process extra sugars that potentially can be stored as fat when the body is under stress. This in itself can prevent weight gain, but in a healthy way. Some people may feel their appetite suppressed a bit, but it’s mostly suppressed against over snacking and sugar cravings.
Cissus should be taken 30 minutes before eating, so the herbal supplements support eating. We probably tend to over eat at single meals anyway, so a natural appetite suppressant shouldn’t have any harm, even to someone anorexic.
Cissus can also be used as an external ointment on both bone fractures and skin burns. It’s anti-oxidant capabilities and over healing powers heal the skin also.
Oxidants and Stress are two major causes of asthma. Cissus carries high levels of anti-oxidants and promotes a healthy chemical balance within the body. Although our only real cures for stress are lifestyle choices and changes, the effects of stress are chemical imbalances within the body which tend to negatively affect our digestion, our weight, and our mood. Cissus Quadrangularis has healing abilities in all these fields, especially in the digestive tract.