Clinical evidence supporting the use of cissus quadrangularis for bone and metabolic health continues to shine. Cissus quadrangularis is a time-honored ayurvedic herb being used for a lot more than one thousand years. Its nickname is “bone setter.” We have explained how cissus quadrangularis helps bones in two recent articles, Cissus Quadrangularis – An Effective Bone Healer and Cissus Quadrangularis: Connecting Bones & Metabolic Health and Wellness. One analysis on cissus quadrangularis and bones reveals that cissus quadrangularis works at the level of gene transcription to ignite osteoblasts and to specifically increase their generation of osteocalcin1. This is an impressive finding, as it indicates that the nutrient is a bone-building gene regulator, lifting it to a new standing of effectiveness. Furthermore, osteocalcin2 function as a hormone in other places in your body by increasing adiponectin3 production in your white adipose tissue, in turn serving to help protect against insulin resistance and cardiovascular inflammation4.

Increased Interest in Cissus Quadrangularis

Increased interest in cissus quadrangularis and metabolism centers around its historical use for hemorrhoids, ulcers, asthma, and constipation– all important issues linked with bacterial imbalance in the intestinal tract. I have detailed the adverse effect of these factors on metabolism in a more recent article, How Digestive Problems Prevent Weight Loss. Science advocates the traditional use of cissus quadrangularis to help treat the cellular lining of the digestive tract, lower inflammation, boost antioxidant defenses, and control bacterial imbalance. Cissus quadrangularis has previously been shown to have antibacterial properties5, including against the Staphylococcus family typically found in surplus in obese individuals. One of the metabolic complications caused by bacterial imbalance is overproduction of harmful LPS, which interferes with metabolism.

Cissus quadrangularis also helps reduce LPS-induced free radical damage6

Cissus quadrangularis also helps reduce LPS-induced free radical damage6, helping counteract this problem in overweight people. It does so by helping lessen both inflammatory nitric oxide (iNOS) and the core inflammatory gene signal NF-kappaB. Another recent analysis revealed cissus quadrangularis to be particularly protective of the liver7, offsetting the toxic effects of a TB drug by substantially lessening free radical damage. This is relevant to weight management, as the liver is oftentimes subject to inflammatory and free radical-producing insults coming from both the digestive tract and white adipose tissue. Thus, cissus quadrangularis serves to help counter metabolic stress linked with digestive tract imbalance by a wide array of mechanisms.

Science confirms the benefit of cissus quadrangularis

Science confirms the benefit of cissus quadrangularis as an useful bone support nutrient, and expands on its role in metabolic support. Not only does cissus quadrangularis help greatly improve metabolism through osteocalcin-boosting adiponectin production, it also lowers toxic stress from digestive tract disproportion — a complication confronted by many who struggle with their body weight.