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Wellness Resources described this new body of science in their cutting-edge article The New World of Bones– Thyroid, Leptin, Blood Sugar, and Bone Strength, which I highly encourage to any one interested in this subject matter.

Bone Health and Metabolic Health are Extremely Linked

In brief, bone constructing cells called osteoclasts manufacture a protein called osteocalcin, which is critical for the buildup of bone. Additionally, osteocalcin acts as a hormone, going to stocked fat where it boosts the generation of adiponectin, consequently helping liver metabolism and preventing insulin resistance and type 2 diabetes. Conversely, bone remodeling cells called osteoclasts, when active in excess, lead to bone reduction. They develop too much of a substance called TRAP (tartrate resistant acid phosphatase), which also goes to fat cells and has the undesirable impact of helping to make a person obese. This information makes it clear that bone health and metabolic health are extremely linked.

There is an effort going on throughout the world aiming to use the cutting-edge science to log many long standing functional utilizations of herbs and plants to sustain health. In a just recently publicized examination cissus quadrangularis was able to stop insulin resistance1, liver damage, fat accumulation, and oxidative damage in animals provided a high fat fructose diet (the regular diet of obese/diabetic Americans). This maintains a 2006 study2 showing that cissus quadrangularis can assist overweight and obese adults reduce weight.

Cissus Quadrangularis can Increase Osteoblast Activity

Additionally current cell and animal research studies reveal that cissus quadrangularis can increase osteoblast activity, which naturally manufactures even more osteocalcin, while minimizing osteoclast activity4 (decreasing TRAP). Earlier animal studies have confirmed the bone mending capability of cissus quadrangularis. In 1964 it was demonstrated that the herb quickened bone fracture healing in dogs and rats by 33 percent. In 1976 detailed examinations of the capacity of osteoblasts to provide renewed bone cells was undergone during fracture healing. At three weeks the cissus quadrangularis administered animals were making remarkable improvement as compared to controls, and at six weeks their recuperation process was finished while the untreated animals were still healing.

Building on this research in 2002 a research study was carried out using cissus quadrangularis extract at a dosage of 250 mg three times daily to help 10 subjects with fracture of the long bones in their leg, whose fractures had been maintained with interlocking nails. The usual healing time for this wound is 16-20 weeks. The healing time for this bunch was 12-14 weeks, verified by X-ray analysis. This is a similar to the 33 percent increased rate of healing witnessed in earlier animal studies.

Cissus Quadrangularis Study

A naturally cultivated standardized extract of cissus quadrangularis has recently been examined in 40 perimenopausal women with low bone density. Study attendees took 250 mg three times per day for six months. By the end of the research study the average improvement in bone density was 17 percent.

Since cissus quadrangularis has no known harmful side effects and a long history of traditional use, the collective body of science shows that it is a natural way to help promote both bone and metabolic health.

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New scientific exploration is helping to report the ability of this extraordinary bone support nutrient.

The most current examination reveals that it directly helps bone marrow make the bone-building carpenter cells known as osteoblasts in addition to directly support the formation of calcium matrix (new bone).

The mesenchymal stem cells inside bone marrow offer the ability to eventually become the critical osteoblasts. They can additionally become macrophages. Metabolic indicating guides what will happen. Excessive inflammation encourages macrophage formation and a scarcity of osteoblasts proportionate to too many osteoclasts, consequently promoting bone loss. Nutrients that support osteoblast development are highly beneficial for bone health.

This study shows that cissus quadrangularis not only assists mesenchymal stem cells develop into osteoblasts but that it also helps encourage the generation of more mesenchymal stem cells, which can then develop into more osteoblasts. This herb contains highly bioactive regeneration abilities for bone.

The investigators concluded that “cissus quadrangularis stimulates osteoblastogenesis and may be utilized as preventive/alternative all-natural medicine for bone diseases such as osteoporosis.”.

References:

1. ^ Cissus Quadrangularis Helps Bone Buiding Cells  Clinics (Sao Paulo).  Potu BK, Bhat KM, Rao MS, Nampurath GK, Chamallamudi MR, Nayak SR, Muttigi MS.

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Increased Interest in Cissus Quadrangularis

Increased interest in cissus quadrangularis and metabolism centers around its historical use for hemorrhoids, ulcers, asthma, and constipation– all important issues linked with bacterial imbalance in the intestinal tract. I have detailed the adverse effect of these factors on metabolism in a more recent article, How Digestive Problems Prevent Weight Loss. Science advocates the traditional use of cissus quadrangularis to help treat the cellular lining of the digestive tract, lower inflammation, boost antioxidant defenses, and control bacterial imbalance. Cissus quadrangularis has previously been shown to have antibacterial properties5, including against the Staphylococcus family typically found in surplus in obese individuals. One of the metabolic complications caused by bacterial imbalance is overproduction of harmful LPS, which interferes with metabolism.

Cissus quadrangularis also helps reduce LPS-induced free radical damage6

Cissus quadrangularis also helps reduce LPS-induced free radical damage6, helping counteract this problem in overweight people. It does so by helping lessen both inflammatory nitric oxide (iNOS) and the core inflammatory gene signal NF-kappaB. Another recent analysis revealed cissus quadrangularis to be particularly protective of the liver7, offsetting the toxic effects of a TB drug by substantially lessening free radical damage. This is relevant to weight management, as the liver is oftentimes subject to inflammatory and free radical-producing insults coming from both the digestive tract and white adipose tissue. Thus, cissus quadrangularis serves to help counter metabolic stress linked with digestive tract imbalance by a wide array of mechanisms.

Science confirms the benefit of cissus quadrangularis

Science confirms the benefit of cissus quadrangularis as an useful bone support nutrient, and expands on its role in metabolic support. Not only does cissus quadrangularis help greatly improve metabolism through osteocalcin-boosting adiponectin production, it also lowers toxic stress from digestive tract disproportion — a complication confronted by many who struggle with their body weight.

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Dr Brijnath Singh, eminant scholar, MD and PhD in Ayurveda and ethnopharmacology wild-cultivates Harjod (Cissus Quadrangularis) in the Vrindavan farm north of Lucknow. Prashanti interviews him on the magic of this herb whose very name means ‘Bone joiner” as it is so rich in the minerals and healing power to support Bone and Joint health.

In this video Dr. Brijnath Singh and Prashanti discuss Harjod, or in latin, Cissus Quadrangularis, in a very detailed discussion with great views of the herb growing on this majestic neem tree in the beautifully culivated farms of India.

View This Video about Cissus on YouTube

Do you have any great videos or pictures with Cissus?

At The Cissus Experts we are always excited to see videos, images, and great information about Cissus Quadrangularis.  If you find any good pics or videos please share them with us as we can share them with our community.

You can email any information about cissus to info@cissus.org or let us know in the comments section below.  Thanks!

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Product Name: SuperCissus
Brand: USP Labs
Quantity: 150 Vegetarian 800mg Capsules
Suggested Serving: Take 2 capsules with breakfast and dinner.
Additional Ingredients: Gelatin, Corn Starch, Magnesium Stearate, Blue 1, Yellow 5, Titanium Dioxide Color

This cissus product looks great on the surface – 800mg capsules, 150 count, and a patented Cissus Extract, however we were really turned off by the additional ingredients.  We understand that these ingredients are just for the capsule and are probably very small amounts, but carcinogens such as blue 1 and yellow 5 should not be put anywhere near just an amazing, ayurvedic medicinal herb.  More care should be taken for the consumers health.  At The Cissus Experts we feel cissus should always be placed in a vegetarian capsule free of magnesium stearate, which actually inhibits the bodies uptake of nutrients.

It is not also stated when herbal supplements contain fillers, but the fact that this is an 800mg capsule and they don’t specify that there are not fillers, we are going to go ahead and assume that there are.  We have tasted many forms of pure cissus and cissus extracts, and this one has a funky color and taste compared to 100% pure cissus.

Maybe the most quantity for your buck (if you buy on Amazon), but definitely not the highest quality.  It seems that Cissus Quadrangularis took off in popularity with the body builders due to it’s cortisol inhibiting and tendon repairing capabilities, cissus is also great for older folks suffering from joint pain and to prevent osteoporosis.  We should be looking for a brand who cares about our core health, and not just getting “ripped”.

Overall, The Cissus Experts do not recommend SuperCissus from USPlabs.  We are not sure what “award” it has won, but until they remove the additional ingredients and go with a more ayurvedic approach we are suggesting to go another route.

Note: Cissus can be found in other supplements and can also be found in non-extract form. Cissus is an anti-oxidant and may be used to enhance a supplement. Only the extract can bring you the full benefits of the plant. Almost all studies found on Cissus use the Extract form.

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Cissus is commonly known as Veldt Grape, Devil’s Backbone, or Winged Treebine.

Cissus in India

Cissus has a long history of medicinal use in India and is commonly referred to as Hadjod, translated as ‘(the one) that unites broken bones’ in Hindi, while its Sanskrit name, asthisamharaka, literally means ‘protecting bones from destruction’.

Cissus in Thailand

In Thai, Cissus is written เพชรสังฆาต, which transliterates to “Phet sang kat” or “Phet Sangkhat”. It is mostly prescribed to relieve hemorrhoids, which is one benefit due to it’s anti-inflammatory properties. Some Thais are learning more about the wide range of benefits of Cissus.

A list of what Cissus Quadrangularis can otherwise be known as:

Asthisonhara, Chadhuri, Chaudhari, Cissus, Cissus Extract, Cissus Formula, Cissus Formulation, C. Quadrangularis, Cissus Quadrangularis, Cissus Quadrangularis Extract, CORE, CQ, CQE, CQR-300, Extrait de Cissus, Hadjod, Hadjora, Harbhanga, Harsankari, Hasjora, Kandavela, Mangaroli, Nalleru, Namunungwa, Phet Cha Sung Khaat, Phet Sang Kat, Phet Sangkhat, Pirandai, Quadrangularis, Samroi To, San Cha Khuat, Stemmed Vine, Vajravalli, Vedhari, Veld Grape, Veldt-grape, Vitis quadrangularis, Winged Treebine.

Scientific Classification of Cissus:

Binomial name: Cissus quadrangularis

Synonyms:  Cissus quadrangula, Vitis quadrangularis

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Cissus Quadrangularis Case Study Excerpt

In addition to speeding the remodeling process of the bone, Cissus also leads to a much faster increase in bone tensile strength. In clinical trials Cissus has led to a fracture healing time in the order of 55 to 33 percent of that of controls.  Cissus exerts antiglucocorticoid properties is suggested by a number of studies where bones were weakened by treatment with Cortisol and upon administration of Cissus extract the Cortisol induced weakening was halted and the healing process begun.

Endogenous Glucorticoids including the body’s endogenous hormone Cortisol activate pathways that degrade not only bone, but skeletal muscle tissue as well. Glucocorticoids induce muscle breakdown. They activate the so-called Ubiquitin-Proteasome pathway of proteolysis. This pathway of tissue breakdown is important for removing damaged and non-functional proteins.

By exerting an anabolic, antiglucocorticoid effect, Cissus preserved muscle tissue during times of physical and emotional stress, which is of more interest to the average bodybuilder or athlete.

Note:  Cissus Extract is best taken first thing in the morning since this is when our cortisol levels are highest.  It is then recommended to take cissus in the late afternoon, 20-30 minutes before dinner or after a heavy workout.

Recommended Dosage:  If you are taking cissus extract just to maintain healthy bones and healthy digestion, the recommended dosage is 1000mg 2 times a day.

If you are taking cissus to heal a bone fracture or an injured tendon/ligament the recommended dosage is 1500-2000mg.

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The Study

This study was designed to investigate the hepatoprotective activity of methanol extract of Cissus quadrangularis against rifampicin-induced hepatotoxicity in rats.The coarse powder of the shade dried stem of Cissus quadrangularis was subjected to successive extraction in a Soxhlet apparatus using solvents petroleum ether (60-80°) and methanol. Liver damage was induced in Wistar rats by administering rifampicin (54 mg/kg, p.o.) once daily for 30 days. Methanol extract of Cissus quadrangularis (500 mg/kg, p.o) was administered 1 h prior to the administration of rifampicin (54 mg/kg, p.o.) once daily for 30 days. Silymarin (50 mg/kg p.o) used as reference drug. Elevated levels of aspartate transaminase, alanine transaminase, alkaline posphatase and bilirubin following rifampicin induction were significantly lowered due to pretreatment with methanol extract of Cissus quadrangularis.

Rifampicin administration significantly increased lipid peroxidation and decreased antioxidant activities like reduced glutathione, superoxide dismutas and catalase. Pretreatment of rats with methanol extract of Cissus quadrangularis significantly decreased lipid peroxidation and increased the antioxidant activities. Histology of the liver section of the animals treated with the methanol extract of Cissus quadrangularis further confirms the hepatoprotective activity. The results of the present study indicated the hepatoprotective effect of methanol extract of Cissus quadrangularis which might be ascribable to its antioxidant property due to the presence of β-carotene.

Conclusion:
It is concluded from the above observations that the methanol extract of CQ has a hepatoprotective activity against rifampicin-induced liver injury. The mechanism of hepatoprotection may be attributed to its antioxidant activity; this in turn is related to the presence of β–carotene.

Note: Most studies done on Cissus, unfortunately used rats as a control where the rats are either put under stress, intoxicated, or sacrificed. The Cissus Experts do not support the harming of animals, but the studies done in India on Cissus have scientifically proven positive effects of cissus quadrangularis on humans and may be used to help humans prevent or fight diseases and injuries.

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RESULTS

Cissus Quadrangularis Prevents Osteoporosis

Treatment with 100, 200 or 300 μg/mL petroleum ether extract of Cissus quadrangularis enhanced the differentiation of marrow mesenchymal stem cells into ALP-positive osteoblasts and increased extracellular matrix calcification. Treatment with 300 μg/mL petroleum ether extract of Cissus quadrangularis also enhanced the proliferation rate of the marrow mesenchymal stem cells. Cells grown in osteogenic media containing Cissus quadrangularis exhibited higher proliferation, differentiation and calcification rates than did control cells.

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