Hepatoprotective Effect of Cissus quadrangularis Stem Extract Against Rifampicin-induced Hepatotoxicity

Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage.  The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents.  Many pharmaceutical medications can have harmful affects to your liver.  Cissus may be a great alternative to counter acting these affects.

The Study

This study was designed to investigate the hepatoprotective activity of methanol extract of Cissus quadrangularis against rifampicin-induced hepatotoxicity in rats.The coarse powder of the shade dried stem of Cissus quadrangularis was subjected to successive extraction in a Soxhlet apparatus using solvents petroleum ether (60-80°) and methanol. Liver damage was induced in Wistar rats by administering rifampicin (54 mg/kg, p.o.) once daily for 30 days. Methanol extract of Cissus quadrangularis (500 mg/kg, p.o) was administered 1 h prior to the administration of rifampicin (54 mg/kg, p.o.) once daily for 30 days. Silymarin (50 mg/kg p.o) used as reference drug. Elevated levels of aspartate transaminase, alanine transaminase, alkaline posphatase and bilirubin following rifampicin induction were significantly lowered due to pretreatment with methanol extract of Cissus quadrangularis.

CISSUS QUADRANGULARIS HEPATOTOXICITY
Rifampicin administration significantly increased lipid peroxidation and decreased antioxidant activities like reduced glutathione, superoxide dismutas and catalase. Pretreatment of rats with methanol extract of Cissus quadrangularis significantly decreased lipid peroxidation and increased the antioxidant activities. Histology of the liver section of the animals treated with the methanol extract of Cissus quadrangularis further confirms the hepatoprotective activity. The results of the present study indicated the hepatoprotective effect of methanol extract of Cissus quadrangularis which might be ascribable to its antioxidant property due to the presence of β-carotene.

Conclusion:
It is concluded from the above observations that the methanol extract of CQ has a hepatoprotective activity against rifampicin-induced liver injury. The mechanism of hepatoprotection may be attributed to its antioxidant activity; this in turn is related to the presence of β–carotene.

CISSUS QUADRANGULARIS HEPATOTOXICITY

 

Note: Most studies done on Cissus, unfortunately used rats as a control where the rats are either put under stress, intoxicated, or sacrificed. The Cissus Experts do not support the harming of animals, but the studies done in India on Cissus have scientifically proven positive effects of cissus quadrangularis on humans and may be used to help humans prevent or fight diseases and injuries.