There have been many studies done to reveal that Cissus Quadrangularis prevents Osteoporosis and promotes stronger, healthier bones. Cissus has been used for many centuries to heal bone fractures and reduce inflammation to injured muscles and bones. In osteoporosis, the bone mineral density (BMD) is reduced, bone microarchitecture deteriorates, and the amount and variety of proteins in bone are altered. There have been many theories to what causes osteoporosis and what can prevent it. Many drugs that are offered can be dangerous due to the side effects. Calcium supplements were said to prevent osteoporosis, but actually don’t because many times the body is unable to absorb the calcium, and this is the reason for the bone deterioration in the first place.
Study showing Cissus Quadrangularis Prevents Osteoporosis
A study done to evaluate the effects of the petroleum ether extract of Cissus quadrangularis on the proliferation rate of bone marrow mesenchymal stem cells shows that Cissus quadrangularis stimulates osteoblastogenesis and can be used as preventive/alternative natural medicine for bone diseases such as osteoporosis.
Mesenchymal stem cells(MSC’s) were cultured in media with or without Cissus quadrangularis for 4 weeks and were then stained for alkaline phosphatase.
The results showed treatment with 100, 200 or 300 µg/mL petroleum ether extract of Cissus quadrangularis enhanced the differentiation of marrow mesenchymal stem cells into ALP-positive osteoblasts and increased extracellular matrix calcification.
Human bone is composed of a mineralized organic matrix and bone cells. Osteoblasts are active mature bone cells that synthesize the organic matrix and regulate the mineralization process. Osteogenesis begins with osteoblast formation and secretion of type I collagen, which makes up about 90% of the organic bone matrix, or the osteoid.
The results clearly show that the Cissus Quadrangularis plant extract enhances the proliferation and differentiation ability of Mesenchymal stem cells into osteoblasts.
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