This excerpt was taken from a case study done with Cissus Quadrangularis. One of the benefits of Cissus is its ability to inhibit the absorption of cortisol into our muscle tissue. This is particularly advantageous for body builders or athletes who are trying to gain more muscle mass. Cortisol also eventually becomes a toxin in our body, so the faster we can release this from the body, the more toxin free we will be.
Cissus Quadrangularis Case Study Excerpt
In addition to speeding the remodeling process of the bone, Cissus also leads to a much faster increase in bone tensile strength. In clinical trials Cissus has led to a fracture healing time in the order of 55 to 33 percent of that of controls. Cissus exerts antiglucocorticoid properties is suggested by a number of studies where bones were weakened by treatment with Cortisol and upon administration of Cissus extract the Cortisol induced weakening was halted and the healing process begun.
Endogenous Glucorticoids including the body’s endogenous hormone Cortisol activate pathways that degrade not only bone, but skeletal muscle tissue as well. Glucocorticoids induce muscle breakdown. They activate the so-called Ubiquitin-Proteasome pathway of proteolysis. This pathway of tissue breakdown is important for removing damaged and non-functional proteins.
By exerting an anabolic, antiglucocorticoid effect, Cissus preserved muscle tissue during times of physical and emotional stress, which is of more interest to the average bodybuilder or athlete.
Note: Cissus Extract is best taken first thing in the morning since this is when our cortisol levels are highest. It is then recommended to take cissus in the late afternoon, 20-30 minutes before dinner or after a heavy workout.
Recommended Dosage: If you are taking cissus extract just to maintain healthy bones and healthy digestion, the recommended dosage is 1000mg 2 times a day.
If you are taking cissus to heal a bone fracture or an injured tendon/ligament the recommended dosage is 1500-2000mg.