Wellness Resources described this new body of science in their cutting-edge article The New World of Bones– Thyroid, Leptin, Blood Sugar, and Bone Strength, which I highly encourage to any one interested in this subject matter.
Bone Health and Metabolic Health are Extremely Linked
In brief, bone constructing cells called osteoclasts manufacture a protein called osteocalcin, which is critical for the buildup of bone. Additionally, osteocalcin acts as a hormone, going to stocked fat where it boosts the generation of adiponectin, consequently helping liver metabolism and preventing insulin resistance and type 2 diabetes. Conversely, bone remodeling cells called osteoclasts, when active in excess, lead to bone reduction. They develop too much of a substance called TRAP (tartrate resistant acid phosphatase), which also goes to fat cells and has the undesirable impact of helping to make a person obese. This information makes it clear that bone health and metabolic health are extremely linked.
There is an effort going on throughout the world aiming to use the cutting-edge science to log many long standing functional utilizations of herbs and plants to sustain health. In a just recently publicized examination cissus quadrangularis was able to stop insulin resistance1, liver damage, fat accumulation, and oxidative damage in animals provided a high fat fructose diet (the regular diet of obese/diabetic Americans). This maintains a 2006 study2 showing that cissus quadrangularis can assist overweight and obese adults reduce weight.
Cissus Quadrangularis can Increase Osteoblast Activity
Additionally current cell and animal research studies reveal that cissus quadrangularis can increase osteoblast activity, which naturally manufactures even more osteocalcin, while minimizing osteoclast activity4 (decreasing TRAP). Earlier animal studies have confirmed the bone mending capability of cissus quadrangularis. In 1964 it was demonstrated that the herb quickened bone fracture healing in dogs and rats by 33 percent. In 1976 detailed examinations of the capacity of osteoblasts to provide renewed bone cells was undergone during fracture healing. At three weeks the cissus quadrangularis administered animals were making remarkable improvement as compared to controls, and at six weeks their recuperation process was finished while the untreated animals were still healing.
Building on this research in 2002 a research study was carried out using cissus quadrangularis extract at a dosage of 250 mg three times daily to help 10 subjects with fracture of the long bones in their leg, whose fractures had been maintained with interlocking nails. The usual healing time for this wound is 16-20 weeks. The healing time for this bunch was 12-14 weeks, verified by X-ray analysis. This is a similar to the 33 percent increased rate of healing witnessed in earlier animal studies.
Cissus Quadrangularis Study
A naturally cultivated standardized extract of cissus quadrangularis has recently been examined in 40 perimenopausal women with low bone density. Study attendees took 250 mg three times per day for six months. By the end of the research study the average improvement in bone density was 17 percent.
Since cissus quadrangularis has no known harmful side effects and a long history of traditional use, the collective body of science shows that it is a natural way to help promote both bone and metabolic health.